Why Wakefield and the MMR story is only partially true at best
Thanks to a number of ‘modern world’ factors, the gut microbiome of children is damaged like no generation before. Damaged from before birth, damaged during birth, damaged after birth. And by the time the MMR vaccine comes along, it is little more than the ‘coup de grace’ for these children.
Autism and the gut
A lot is now understood about autism.
Kids with autism often have severe gut problems – for example, they are twice as likely as children with other types of disorders to have frequent diarrhoea or colitis, an inflammation of the large intestine. GI problems are frequent anyway in children with autism; pain and constipation are more common.
A study(1) by Rosa Krajmalnik-Brown and Jin Gyoon of Arizona State’s Biodesign Unit researchers showed that kids with autism had a greatly reduced spectrum of gut bacteria. One in particular, Prevotella, was missing completely.
Research studies (and there are many) have clearly indicated that poor levels of gut bacteria can trigger inflammation which reaches the brain.
Many children nowadays have a damaged gut microbiome
So how does damage (typically a lowered volume and lowered diversity of commensal or ‘good’ bacteria) occur in the infant gut?
A healthy baby picks up bacteria largely in three ways
1. By passing through the birth canal
2. By being breast fed
3. By bacteria from mother’s illness: Surprisingly, the womb is not inert and bacteria have also been shown to be picked up from, for example, type-2 diabetic mothers.
So, it is likely that there is a matrix of factors causing lowered commensal bacteria and heightened pathogens – for example,
i. Babies born to mothers with abnormal vaginal bacteria (due to drugs, prescribed or otherwise, or even stress). One study showed that expectant mothers who had taken antibiotics in the year before conceiving had babies with less commensal bacteria.
ii. Babies born by Caesarian clearly have less ‘good’ guys.
iii. Children having antibiotics early in life have damage.
iv. Babies not breast fed.
v. Babies born to mothers who are ‘ill’.
So these factors and more can leave young children with less good guys and more pathogens, especially since the prime bacteria gained from a healthy mother who is breast feeding are strains of Bifidobacterium and these are very strong in their control of pathogens in the first 6 to 12 months of life.
Gut bacteria ‘control’ your immune system
Your gut bacteria control 85 per cent of your immune system and immune memory. This happens through an ‘action and reaction’ system. A child touches the dog and then sucks her fingers immediately introducing new bacteria into the body. There’s a reaction, and new ‘tailored’ white cells are made, providing protection for life, if the invaders stick around.
Gut bacteria control your mental state
And we also know that changes in the gut affect the brain. In Cell, Dec 19th, 2013, University of Colorado Boulder Professor Rob Knight commented on the first study from a group of American researchers in the newly formed Autism Microbiome Consortium, saying, “This study strengthens the scientific understanding that what goes on in your gut affects what goes on in your brain”.
They induced autism symptoms in mice, which were greatly reduced when the mice were fed the bacterium Bacteriodes fragilis. Researchers found that levels of 4-ethylphenylsulfate were 46 fold heightened in mice with autism-like symptoms but Bacteriodes fragilis reduced these levels to normal.
The clash between gut bacteria and vaccines
Your protective white cells largely form in response to invasive gut bacteria. The obvious question then is, ‘so what is the relationship with vaccines which are also basically designed to prompt an immune reaction?’
The skeptics point to the dangers of introducing foreign DNA and RNA contained in vaccines into your body, especially now we understand what it can do in the microbiome. We already know, for example, that certain Japanese island fishermen have taken DNA into their own DNA over the years from the sea kelp they have consumed.
We are also clear on the potential damage of carriers such as Thimerosal, (mercury), and other sometime ingredients like formaldehyde, aluminium, MSG, methanol, antibiotics and even nagalase. No one can possibly say these have no effect. Even the American Government does not claim vaccines are 100 per cent safe, as we told you in the Previous article ‘The Truth about Vaccines’.
Vaccinations have a greatly reduced effect with strong microbiomes
A big clue to the relationship between vaccines and the strength of the gut microbiome lies with vaccination in the African Continent. There, children can have very strong microbiomes and often vaccination is being shown to fail. The strong microbiome ‘deals’ with the intruder pathogen!
In a 2011 paper(2), researchers from Canada noted that clinical trials showed oral vaccines against polio, rotavirus and cholera had less efficacy and blunted immune response with individuals in developing nations. In these cases, they stated, the individuals have greater gut bacteria diversity than individuals in the developed world and those ‘defences’ don’t just deal with illnesses, they deal with the vaccine components too.
In 2013, studies(3,4) resulting from a collaborative effort between the University of Maryland School of Medicine Institute for Genome Sciences and the Center for Vaccine Development backed this up.
The first study examined the impact of an oral typhoid vaccination on the gut bacteria; the second looked at the impact of vaccines against Shigella, but this time in monkeys. And a third study looked into what happens when the gut bacteria are exposed to wild-type Shigella, which as with S. Typhi, gain access to the body orally (PLOS ONE).
The first conclusion was that the magnitude of the natural immune response depended on the existing diversity of gut bacteria. The more diverse the existing gut bacteria, the greater the resistance to infection by wild type Shigella. No surprises there really.
But the greater the diversity of gut bacteria, the more the characteristics and magnitude of the immune responses to the vaccines were too.
“Our research raises the intriguing possibility that the gut microbiota may play an important role in response to vaccines and susceptibility to enteric pathogens, or bacteria that affect the intestinal tract,” stated Claire M. Fraser, PhD, professor of the Departments of Medicine and Microbiology and Immunology and director of the Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine.
The other study analysed what happened to the human gut microbiota when an oral typhoid vaccination using Salmonella Typhi (S. Typhi) was given. Sure enough, the gut bacteria were affected; and it seems that the more diverse the microbiome members, the stronger the immune responses against the vaccine.
So does MMR cause autism?
There is far, far more in my book, ‘Heal your gut, heal your body’, but it is clear that a weakened microbiome and a loss of commensal bacteria is the major factor in autism.
Sure, vaccines don’t help. To put this in context, a child in America, if the Government CDC recommendations are followed to the letter, will receive 49 doses of vaccines in 14 shots by the age of six. By the age of 18 this reaches 69 doses in 16 shots.
And this is the problem. It is a huge load on an already imperfect microbiome.
Clearly there are factors in MMR vaccines which are toxic to a child’s gut bacteria anyway. And the genetic material in MMR is classified as live/attenuated. So it’s not a truly ‘safe’ vaccine.
But if the gut microbiome of the child was perfect and 100 per cent strong would the MMR vaccination have any negative effect at all? I doubt it very much, as the studies from Africa suggest. I’d be far more worried about the over-use of antibiotics on the very young.
Ref 1: Rosa Krajmalnik-Brown, Jin Gyoon; PLOS ONE, July 3rd, 2013
Ref 2: Rosana B. R. Ferreira, L. Caetano M. Antunes, and B. Brett Finlay, Glenn F. Rall, Editor; PLoS Pathog. 2010 November; 6(11): e1001190. Published online 2010 November
Ref 3: Anna M. Seekatz, Aruna Panda, David A. Rasko, Franklin R. Toapanta, Emiley A. Eloe-Fadrosh, Abdul Q. Khan, Zhenqiu Liu, Steven T. Shipley, 2. Louis J. DeTolla, Marcelo B. Sztein, Claire M. Fraser. Differential Response of the Cynomolgus Macaque Gut Microbiota to Shigella Infection. (PLoS ONE, 2013; 8 (6): e64212 DOI: 10.1371/journal.pone.0064212)
Ref 4: Emiley A. Eloe-Fadrosh, Monica A. McArthur, Anna M. Seekatz, Elliott F. Drabek, David A. Rasko, Marcelo B. Sztein, Claire M. Fraser. Impact of Oral Typhoid Vaccination on the Human Gut Microbiota and Correlations with S. Typhi-Specific Immunological Responses. (PLoS ONE, 2013; 8 (4): e62026 DOI: 10.1371/journal.pone.0062026)
Help, I’m sick – orthorexia nervosa. I have it. Badly!
You see, at all times I want to eat healthily. True I drink a glass of red wine (or two) a day, but I think that is healthy too. I grow all my own vegetables, eat foods like flaxseed and nuts, squeeze oranges, use Extra Virgin Olive Oil and eat sourdough bread. And shhhhh, don’t tell anyone; I eat fresh pomegranate and papaya from the garden, make up wheatgrass juice and put apricot kernels in my whole oat porridge, the thought police just might arrest me.
No wonder those spotty, sit–in-front-of-their-computer-screens-eating-Pizza skeptics think I’m a quack. I still play football. And go to the gym. At 65. No hope really.
And now it’s official. In America, wanting to eat healthily is AN ILLNESS. It’s all over the media. The psychiatric profession has spoken. Those people who hand out drugs to control people’s moods and ‘mental’ conditions (when they don’t know for sure how the drugs actually work), have spotted a new mental condition:
Orthorexia nervosa. It’s a desire to eat healthily and is characterised by wanting to eat ‘clean’ or ‘healthy’ foods. Apparently sufferers are overly concerned by the nutritional make up of what they eat. They have even been known to read labels in Supermarkets and check ingredients.
No it’s not April 1st.
So that’s it – I have an official ‘eating disorder’, because I don’t fancy a frozen beefburger (with tomato ketchup and French Fries), a can of coke and a slice of cheesecake, nor a TV dinner fresh from the microwave. What hope is there for me?
Will I now be declared a raving loony and my passport endorsed? Will the psychiatrists work with the drugs companies to develop a drug to change my mental state and treat me? Or will I be forced into rehab – and have to spend a week eating at McDonalds or Pizza Hut? Maybe I’ll be connected to a pesticide drip? Maybe all ingredients labels will be removed from food packaging in Supermarkets to protect me from my urges.
On my trip back to the UK, there was discussion on TV suggesting fat people were given financial incentives to diet; and smokers were given cash to stop smoking. Clearly Big Brother is going mad.
A few years back when Codex was stopping herb sales in Europe, I did actually write a piece entitled ‘What next? Oranges?’
So, maybe it’s my fault? Maybe a psychiatrist read it?
If they want to read something new on their chosen subject perhaps they could go to Scientific American vol 312, where, in the ‘Mind and Brain’ section, there’s an article on how the bacteria in your gut control your mental state – as I’ve been telling people for two years now.
Taking specific probiotics would potentially make psychiatric drugs (and psychiatrists) redundant.
A Whistleblower stirs up a frenzy on Autism, MMR and the CDC in America
A ‘Whistleblower’, Dr William Thompson, a senior scientist at the Centers for Disease Control and Prevention in the USA has publicly stated that the CDC withheld data that confirmed a link between MMR and Autism.
The word ‘fraud’ is commonly used in press comment about the CDC action.
And in the last two days, there has been release of messages supposedly sent to Dr Andrew Wakefield by Thompson apologising for his ‘dishonesty’ and the effect it had on Wakefield’s life.
Let us just follow this through because the blogging press – for Wakefield, cover ups, MMR and Autism has been having a field day.
Dr Andrew Wakefield is a British former surgeon, medical researcher and honorary consultant in experimental gastroenterology at the Royal College of Pathologists, best known for his 1998 research paper claiming that there was a link between the administration of the MMR vaccine and the appearance of autism and bowel disease.
The controversy was enormous. Wakefield has continued to defend his research and conclusions, while Sunday Times reporter Brian Deer, in particular, has aggressively attacked Wakefield and produced evidence in support of his claims. On 28th January a GMC tribunal found charges (including dishonesty) proven against Wakefield and in May 2010 Wakefield was struck off the Medical Register.
Critics claim he has cost ‘countless’ lives (never seemingly quantified) because of his ‘untrue claims’ and thus parents did not vaccinate their children with MMR; while Wakefield himself has always maintained that there was a smear campaign against him, funded by Pharmaceutical Companies and often using skeptics and paid anonymous bloggers. (Ed: Surely not?)
Wakefield now lives in Austin, Texas where he has a number of business and charitable interests mainly to do with Autism.
Ten days ago a news story broke in America. Typically the headlines used phrases such as
“Whistleblower speaks out about MMR and CDC fraud”.
A second round of comments has occurred in the last two days – typically:
“Whistleblower Thompson apologises to Dr Andrew Wakefield”.
What is this all about? Read this comment from Natural News in America.
‘Whistleblower William Thompson has now gone public with a statement posted on the website of the law firm representing him, Morgan Verkamp LLC.
‘My name is William Thompson. I am a Senior Scientist with the Centers for Disease Control and Prevention, where I have worked since 1998. I regret that my co-authors and I omitted statistically significant information in our 2004 article published in the journal Pediatrics. The omitted data suggested that African American males who received the MMR vaccine before age 36 months were at increased risk for autism. Decisions were made regarding which findings to report after the data were collected, and I believe that the final study protocol was not followed.’
Furthermore Natural News states: The statement (above) opens with a blatant admission of scientific fraud at the CDC:
There are a few immediate comments one needs to add. A Whistleblower to me is someone who rushes off to the mainstream media to tell about dirty deeds. Thompson here held a private chat with someone he did not know was recording him, nor was going to publish along with his name. That doesn’t, of course, affect the content, which has now been verified by CNN.
Thompson also makes the point that the data suggested one group of Americans (African Americans) did seem to have an increased risk of Autism from MMR. Not that all the people in the study had an increased risk.
The fact is that incidence of gastrointestinal problems is high in children with autism. Here is an excerpt from Chris Woollams new book ‘The SECRET SOURCE of Your Good Health’:
‘In a 2013 meta-analysis of available research ‘Gastrointestinal Concerns in Children with Autism: What do we know?’ for the Autism Science Foundation in America, Doctors Barbara McElhanon of Emory School of Medicine and William Sharp of the Marcus Autism Center in Atlanta observed that:
i) There has been a rapid increase in the numbers of cases to 1 in 88 children born according to the CDC, 2012). This has prompted a level of urgency amongst carers.
ii) There has been frequent reporting of gastro- intestinal symptoms (Croen et al., 2012).
iii) There has been a fivefold increase in reported cases of feeding problems (Sharp et al., 2013).
The results of the meta-analysis suggested children with ASD are at increased risk for gastrointestinal issues (1). Specifically, greater levels of gastrointestinal symptoms reported by parents compared with siblings (roughly an 8 fold increase in the risk) with areas of specific concern including abdominal pain, constipation, and diarrhoea.
Certainly there is 2012 research showing that kids with autism were twice as likely as children with other types of disorders to have frequent diarrhoea or colitis (an inflammation of the large intestine).
Researchers from Arizona State University’s Biodesign Institute have shown that autistic children have different gut bacteria to ‘normal’ children with one species of gut bacterium completely missing.
Research (2) into gut bacteria and autism is gathering pace.
Teams of researchers at America’s top Universities are studying the connection between your gut bacteria and your brain and specifically how they affect mood swings, attitudes and diseases from Autism to Alzheimer’s. For example, at UCLA, Professor Emeran Mayer M.D. has been studying the link between the bacteria in your gut and how your brain functions. An analysis of 60 humans showed that different regions of the brain were stimulated as a result of the dominance of different gut bacteria.
In a third study (3) there was a clear finding that the bacteria in a child’s gut affects its brain development. “The data suggests that there is a critical period early in life when gut microorganisms affect the brain and change the behavior in later life,” commented Dr. Rochellys Diaz Heijtz, lead researcher.
Of course, none of this proves that vaccines, and specifically MMR, cause autism. Indeed, one research study showed there was an increase in autism risk with mothers who had ‘unusual’ bacteria in their birth canal. The Arizona State research mentioned above stated that unusual bacteria may first enter the baby during transit of the birth canal. It also suggested that stressed mothers can have stressed babies and that the relevant bacteria are also passed during the passage through the birth canal.
But the fact is that autism levels are increasing, gut bacterial composition has been linked to brain development, and drugs and vaccines can definitely influence such bacteria.
The $173 million human microbiome project in the USA, along with its European twin shed important light on the role of the microbiome in your health – and the inconvenient truth that vaccines and drugs damage it. Research is gathering pace in this area. It won’t be long before we really do know the truth. Let’s hope it is not too long. Because autism is for life – at the moment it can be managed to a degree but not cured.
(1) Buie T, Campbell DB, Fuchs GJ 3rd, Furuta GT, Levy J, Vandewater J, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010;125(suppl 1):S1-18
(2)Mulle JG, Sharp WG, Cubells JF. The gut microbiome: a new frontier in autism research. Curr Psychiatry Rep. 2013;15(2):337. doi: 10.1007/s11920-012-0337-0. Epub 2013 Feb 15
(3) Collaboaration between the Karolinska Institute in Sweden and the Genome Institute in Singapore in 2011 – looked at the effect of gut bacteria on brain development in mice (PNAS)
Glyphosphate in Roundup and very disturbing research about Parkinson’s, cancer and other chronic diseases.
A new research report by Anthony Samsel, a retired science consultant, and Dr. Stephanie Seneff, a research scientist at the Massachusetts Institute of Technology has some very disturbing conclusions for the weed killer Roundup and its active ingredient glyphosphate, widely used on GMO products which have been engineered to withstand the large doses that are used to kill the weeds.
In April, the weedkiller was linked to Parkinson’s with an article in the Daily Mail covering the research in the UK (http://www.dailymail.co.uk/news/article-2315057/Is-worlds-popular-weed-killer-causing-Parkinsons-New-study-shows-Roundup-herbicide-linked-cancer-infertility.html#ixzz2WjxIGpZV).
‘Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body,’ the study says.
‘We have hit upon something very important that needs to be taken seriously and further investigated,’ Seneff said.
The Environmental Protection Agency is conducting a standard registration review of glyphosate and has set a deadline of 2015 for determining if glyphosate use should be limited. The study is among many comments submitted to the agency.
Manufacturer Monsanto has always argued that Roundup is safe and “minimally toxic” to humans. But the research report in the journal Entropy, tells a different story:
i. Glyphosphate residues, found in many everyday foods due to its use with GM sugar, corn, wheat and soy, ‘enhance the damaging effects of other food-borne chemical residues and toxins in the environment to disrupt normal body functions and induce disease’. “Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body.”
ii. Glyphosphate greatly affects CYP proteins (for example, cytochrome P450). These were, for example, the focus of attention for Professors Potter and Burke in their work on Salvestrols.
CYP proteins can perform many functions, for example detoxifying ‘foreign’ chemical compounds in your body.
CYP1B1 is directly linked to cancer; even being used as a marker for the disease.
iii. Glyphosphate also destroys gut bacteria and thus the important bioactive products they release from the foods you eat or, indeed, make themselves. With glyphosphate poisoning the bacteria make reduced supplies of amino acids and this plus the glyphosphate interferes with the sulphur system in the body – essential in the fight against cancer and many diseases from gastro-intestinal diseases to MS.
‘Glyphosphate’s claimed mechanism of action in plants is the disruption of the shikimate pathway, which is involved with the synthesis of the essential aromatic amino acids, phenylalanine, tyrosine, and tryptophan. The currently accepted dogma is that glyphosphate is not harmful to humans or to any mammals because the shikimate pathway is absent in all animals.
However, this pathway is present in gut bacteria, which play an important and heretofore largely overlooked role in human physiology’, said the authors.
Readers should look at the CANCERactive article on The Microbiome and its importance to your good health (Link: http://www.canceractive.com/cancer-active-page-link.aspx?n=3431).
Readers might also like to read about Salvestrols. (Link: http://www.canceractive.com/cancer-active-page-link.aspx?n=3205)
1. Green Media info: http://www.greenmedinfo.com/blog/lethality-roundup-weedkiller-may-extend-beyond-plants-humans-study-shows
2. Nation of Change: http://www.nationofchange.org/monsanto-s-roundup-herbicide-may-be-most-important-factor-development-autism-and-other-chronic-disea
3. Mercola: http://articles.mercola.com/sites/articles/archive/2013/06/09/monsanto-roundup-herbicide.aspx